Lupus Therapeutics and LuCIN Clinical Studies

Lupus Therapeutics has been involved in some of today’s most important breakthroughs in lupus research. And today, we’re helping to guide what we hope will be future breakthroughs.

Lupus Therapeutics and LuCIN Clinical Studies

Lupus Therapeutics has been involved in some of today’s most important breakthroughs in lupus research. And today, we’re helping to guide what we hope will be future breakthroughs.

Lupus Therapeutics and LuCIN Clinical Studies

Lupus Therapeutics has been involved in some of today’s most important breakthroughs in lupus research. And today, we’re helping to guide what we hope will be future breakthroughs.

The Lupus Clinical Investigators Network (LuCIN)
LuCIN is a clinical trials network comprised of 57 of the most reputable academic research medical centers throughout North America. LuCIN brings together the biopharmaceutical industry and academic lupus experts to evaluate the safety and effectiveness of potential new therapies for lupus.

The investigators and other specialized personnel within LuCIN are experts at planning and conducting lupus clinical research on new investigational drugs or repurposed drugs that have already been extensively tested for other diseases and found to be safe.

To learn more about the current portfolio of ongoing clinical trials being conducted within LuCIN as of June 2021, please continue reading below.

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of BIIB059 in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Nonbiologic Lupus Standard of Care

20 LuCIN sites (U.S. and Canada)
Study Status: Not Yet Recruiting

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A Phase 2 Randomized, Double-Blind, Placebo Controlled Efficacy and Safety Study of VIB7734 for the Treatment of Moderate to Severely Active Systemic Lupus Erythematosus

7 LuCIN sites (U.S.)
Study Status: Not Yet Recruiting

Coming Soon

A Phase 2b Dose Ranging Study to Evaluate the Efficacy and Safety of Efavaleukin Alfa in Subjects with Active Systemic Lupus Erythematosus With Inadequate Response to Standard of Care Therapy

20 LuCIN sites (U.S. and Canada)
Study Status: Actively Recruiting

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A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

34 LuCIN sites (U.S. and Canada)
Study Status: Actively Recruiting

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A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE) With Inadequate Response to Standard of Care (SOC) Therapy

Study Sponsor: Amgen, Inc.
24 LuCIN sites (U.S. and Canada)
Study Status: Actively Recruiting

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Dynamic Imaging of Variation in Lupus Nephritis

7 LuCIN sites (U.S. only)
Study Status: Enrollment Complete

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A Phase II, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Study To Evaluate the Safety and Efficacy of M2951 in Subjects With Systemic Lupus Erythematosus (SLE)

Study Sponsor: EMD Serono
7 LuCIN sites (U.S. only)
Study Status: Completed

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A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of CC-220 In Subjects With Active Systemic Lupus Erythematosus

23 LuCIN sites (U.S. and Canada)
Study Status: Enrollment Complete

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A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Subjects With Active Systemic Lupus Erythematosus

Study Status: Enrollment Complete

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A Double-Blind, Placebo-Controlled Randomized, Multicenter Study to Assess Changes in Omega-3 Index in Erythrocytes and Health Benefit After 24 Weeks of Daily Consumption of AKBM-3031 (Omega-3 Phospholipids From Krill), Followed by a 24 Week Open-Label Extension, in Patients With Systemic Lupus Erythematosus (SLE)

20 LuCIN sites (U.S. and Canada)
Study Status: Enrollment Complete

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A Phase 2, Randomized, Double-blind, Placebo-controlled Evaluation of the Safety and Efficacy of BMS-986165 With Background Treatment in Subjects With Lupus Nephritis

18 LuCIN Sites (US and Canada)
Study Status: Actively Recruiting

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A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy and Safety of BMS-986165 in Subjects With Systemic Lupus Erythematosus

22 LuCIN sites (U.S. and Canada)
Study Status: Enrollment Complete

Learn more

A Randomized, Double-Blind, Active Comparator-Controlled, Crossover Study to Assess the Capacity of RAYOS® Compared to Immediate-Release Prednisone to Improve Fatigue and Control Morning Symptoms in Subjects With Systemic Lupus Erythematosus

21 LuCIN sites (U.S. only)
Study Status: Completed

Learn more

A Phase 1b Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of TAK-079 in Combination With Standard Background Therapy in Patients With Moderate to Severe Systemic Lupus Erythematosus

9 LuCIN sites (U.S.)
Study Status: Actively Recruiting

Learn more

Validation of a Mobile Phone Based on EPRO Tool in Subjects With Systemic Lupus Erythematosus

10 LuCIN sites (U.S. and Canada)
Study Status: Completed

Learn more

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Guselkumab in Subjects With Active Lupus Nephritis

8 LuCIN sites (U.S. only)
Study Status: Actively Recruiting

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A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of LY3471851 (NKTR-358) in Adults With Systemic Lupus Erythematosus

15 LuCIN Sites (U.S. and Canada)
Study Status: Actively Recruiting

Learn more

To learn more about the current portfolio of ongoing clinical trials being conducted within LuCIN as of January 15, 2021, please continue reading below.

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

34 LuCIN sites (U.S. and Canada)
Study Status: Study start-up/Not actively recruiting

Learn more

A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE) With Inadequate Response to Standard of Care (SOC) Therapy

Study Sponsor: Amgen, Inc.
24 LuCIN sites (U.S. and Canada)
Study Status: Actively recruiting

Learn more

Dynamic Imaging of Variation in Lupus Nephritis

7 LuCIN sites (U.S. only)
Study Status: Enrollment Complete

Learn more

A Phase II, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Study To Evaluate the Safety and Efficacy of M2951 in Subjects With Systemic Lupus Erythematosus (SLE)

Study Sponsor: EMD Serono
7 LuCIN sites (U.S. only)
Study Status: Enrollment Complete

Learn more

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of CC-220 In Subjects With Active Systemic Lupus Erythematosus

23 LuCIN sites (U.S. and Canada)
Study Status: Enrollment Complete

Learn more

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Subjects With Active Systemic Lupus Erythematosus

Study Status: Enrollment Complete

Learn more

A Double-Blind, Placebo-Controlled Randomized, Multicenter Study to Assess Changes in Omega-3 Index in Erythrocytes and Health Benefit After 24 Weeks of Daily Consumption of AKBM-3031 (Omega-3 Phospholipids From Krill), Followed by a 24 Week Open-Label Extension, in Patients With Systemic Lupus Erythematosus (SLE)

20 LuCIN sites (U.S. and Canada)
Study Status: Actively Recruiting

Learn more

A Phase 2, Randomized, Double-blind, Placebo-controlled Evaluation of the Safety and Efficacy of BMS-986165 With Background Treatment in Subjects With Lupus Nephritis

18 LuCIN Sites (US and Canada)
Study Status: Actively recruiting

Learn more

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy and Safety of BMS-986165 in Subjects With Systemic Lupus Erythematosus

22 LuCIN sites (U.S. and Canada)
Study Status: Actively Recruiting

Learn more

A Randomized, Double-Blind, Active Comparator-Controlled, Crossover Study to Assess the Capacity of RAYOS® Compared to Immediate-Release Prednisone to Improve Fatigue and Control Morning Symptoms in Subjects With Systemic Lupus Erythematosus

21 LuCIN sites (U.S. only)
Study Status: Enrollment Complete

Learn more

A Phase 1b Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of TAK-079 in Combination With Standard Background Therapy in Patients With Moderate to Severe Systemic Lupus Erythematosus

9 LuCIN sites (U.S.)
Study Status: Actively recruiting

Learn more

Validation of a Mobile Phone Based on EPRO Tool in Subjects With Systemic Lupus Erythematosus

10 LuCIN sites (U.S. and Canada)
Study Status: Completed

Learn more

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Guselkumab in Subjects With Active Lupus Nephritis

8 LuCIN sites (U.S. only)
Study Status: Actively Recruiting

Learn more

A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of LY3471851 (NKTR-358) in Adults With Systemic Lupus Erythematosus

15 LuCIN Sites (U.S. and Canada)
Study Status: Actively Recruiting

Learn more